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CRISPR/Cas9

Date:

March 2017

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The CRISPR / Cas system is one of the most important scientific discoveries of recent years. With the help of this genome editing method, DNA can be changed quickly, easily and very precisely.

Figure: Functionality of the CRISPR / Cas9 system for changing DNA in the nucleus. A RNA (guide RNA) molecule guides the nuclease Cas9 to a specific site in the genome, where Cas9 cuts both DNA strands (double-strand breaks). The repair mechanism of the cell repairs the DNA using a targeted mutation. The addition of a DNA strand can also be used to modify and repair genes.

Accompanying Material

Task Sheet

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Material: CRISPR/Cas9

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Graphic CRISPR/Cas9

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GSCN Video about cell therapy with CRISPR/Cas

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The research of Hubert Serve (University hospital Frankfurt)

Max-Planck-Gesellschaft: Video CRISPR/Cas9

The discovery that even bacteria with a kind of immune system can defend themselves against viruses has initially inspired only microbiologists. Since then, however, it has become known that the genome of a wide variety of organisms can be manipulated with the system known as CRISPR / Cas9, and non-scientists are also interested in the new gene technology method. But how does the method with the unspeakable name work?